Sex differences in the cancer proteome
Objectives Proteins play a central role in cancer biology. They are the most common drug targets and biomarkers. Sex influences the proteome in many diseases ranging from …
Metapipeline-DNA: A comprehensive germline and somatic genomics Nextflow pipeline
The price, quality, and throughput of DNA sequencing continue to improve. Algorithmic innovations have allowed inference of a growing range of features from DNA sequencing data, …
yash-patel
HDL from 36-h fasted participants potently promotes efflux of cholesteryl ester from activated microglia
The potential impact of lifestyle changes such as prolonged fasting on brain health still remains unclear. Neurodegenerative diseases often exhibit two key hallmarks: accumulation …
joanne-k.-agus
Identification of non-canonical peptides with moPepGen
Proteogenomics is limited by the challenge of modeling the complexities of gene expression. We create moPepGen, a graph-based algorithm that comprehensively generates non-canonical …
A Co-clinical Trial of Exercise Therapy in Breast Cancer Prevention
Purpose: We conducted a mouse–human co-clinical trial to evaluate the biological efficacy of exercise therapy in breast cancer prevention. Patients and Methods: In a phase I …
lee-w.-jones
The Proteogenomics of Prostate Cancer Radioresistance
Prostate cancer is frequently treated with radiotherapy. Unfortunately, aggressive radioresistant relapses can arise, and the molecular underpinnings of radioresistance are …
roni-haas
NFTest: automated testing of Nextflow pipelines
Motivation The ongoing expansion in the volume of biomedical data has contributed to a growing complexity in the tools and technologies used in research with an increased reliance …
yash-patel
A single 36-h water-only fast vastly remodels the plasma lipidome
Background: Prolonged fasting, characterized by restricting caloric intake for 24 h or more, has garnered attention as a nutritional approach to improve lifespan and support …
brian-v.-hong
Human fasting modulates macrophage function and upregulates multiple bioactive metabolites that extend lifespan in Caenorhabditis elegans: a pilot clinical study
Background Periodic prolonged fasting (PF) extends lifespan in model organisms and ameliorates multiple disease states both clinically and experimentally owing, in part, to its …
christopher-rhodes
Regio-Specific N-Glycome and N-Glycoproteome Map of the Elderly Human Brain With and Without Alzheimer’s Disease
The proteins in the cell membrane of the brain are modified by glycans in highly interactive regions. The glycans and glycoproteins are involved in cell–cell interactions that are …
jennyfer-tena