Quantitative glycoproteomics of high-density lipoproteins

Jan 1, 2022·
Xinyu Tang
,
Maurice Wong
,
Jennyfer Tena
Chenghao Zhu
Chenghao Zhu
,
Christopher Rhodes
,
Qingwen Zhou
,
Anita Vinjamuri
,
Armin Oloumi
,
Sucharita Boddu
,
Guillaume Luxardi
,
Emanual Maverakis
,
Carlito B. Lebrilla
,
Angela M. Zivkovic
· 0 min read
Abstract
In this work, we developed a targeted glycoproteomic method to monitor the site-specific glycoprofiles and quantities of the most abundant HDL-associated proteins using Orbitrap LC-MS for (glyco)peptide target discovery and QqQ LC-MS for quantitative analysis. We conducted a pilot study using the workflow to determine whether HDL protein glycoprofiles are altered in healthy human participants in response to dietary glycan supplementation.
Type
Publication
RSC Advances
publications
Chenghao Zhu
Authors
Chenghao Zhu
Research Assistant Professor
Chenghao Zhu is a Research Assistant Professor in the NCI-designated Cancer Center at Sanford Burnham Prebys. His research focuses on developing computational methods and software for proteogenomics and applying proteogenomics to cancer diagnosis, prognosis, and clinico-epidemiologic questions.